HIV pre-exposure prophylaxis, or PrEP, is a highly effective means for persons without HIV to prevent acquisition of the infection. PrEP is a key intervention under the U.S. government’s new national initiative to reduce to new HIV infections to fewer than 3,000 (<1.0 per 100,000 population) by 2030 under the “Ending the HIV Epidemic”. Under this initiative efforts to scale up PrEP in the U.S. are increasing. Within the blood and tissue donation communities, concerns are being raised that PrEP use may complicate assessment of potential donors’ risk for HIV infection that could lead to inadvertent HIV transmission. In this session, we will evaluate these considerations and how we evaluate potential donors.

Learning Objectives:

• Describe the principals of pre-exposure prophylaxis (PrEP).
• Describe current U.S. government objectives related to PrEP and the “Ending the HIV Epidemic” initiative.
• Describe at least three scenarios in which PrEP use may complicate assessment of potential donors’ risk for HIV infection.
• Summarize considerations in donor screening and risk assessment.