Overtime we have seen the number of acceptable donors decrease due to the increase in “sepsis” in a donor medical chart. An examination of our screening process revealed that the way we asked questions, how we reviewed charts and changes that hospitals made when evaluating a patient for possible sepsis have been responsible for some of the decline in the numbers of acceptable donors. In the past a potential donor could be found unsuitable because the donor was reported to be septic or possibly septic or the COD was reported to be sepsis or probable sepsis at initial screening. Sometimes sepsis showed up in a physician note or a review of specific laboratory data which led us to believe that the patient was possibly septic. The challenge was to develop new screening processes to help identify those donors who may not actually be septic while at the same time ensuring that we work within the FDA and AATB regulations. Other organizations, like ourselves, have developed new processes for screening. Though the processes differ in their design and degree of simplicity their goal is the same which is to be able to identify with some degree of accuracy those donors who may not be septic at the time of death. Examples include changing how questions are asked at initial screening, using an algorithm when reviewing a medical chart and even eliminating the need for Call Center personnel to review laboratory data. Today we will go over some of the changes we made, review our algorithm and discuss the advantages and disadvantages to screening this way.